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The New

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All of these images were acquired using our our new MezoScope systems.

Use the Zoomify browsers below (might need flash) to navigate the large gigapixel images.

A large scale image of a whole 'fresh' aortic valve using dual-polarized illumination. Notable are the thick collagen fibers that extend from the periphery toward the center (especially see the upper right corner). Each fiber appears to branch and 'fan-out' into pinnate fiber structures and membranes. This image is 16x9 tiles (~1 um/pix) acquired using automatic per-tile focus.
Note: This image illustrates a novel feature of the AutoScope3D and Mezoscope, the ability to acquire images of 'thick' specimens under a wide range of illumination options. You can also develop your own custom focusing and imaging algorithms using our custom plug-in modular software and illumination options.

A large scale image of a breast biopsy sample. Notable are the lacunae and cellular strucures. Large scale images (this one is 12x14 tiles) like this can provide new insights into large scale structures, at both 'mezoscopic' and cellular level detail.

Elliptically polarized light image of a breast tissue specimen. The colors are a product of the 'birefringence' property of collagen (bright fibers) that are differentially contrast enhanced under polarized light. The open architecture of the Mezoscope allows a wide range of imaging modalities (taken using a PixeLink PL-H968A camera, 220ms exposure, 12x9 frames/tiles).

Partially polarized light image of a breast tissue specimen. Partial polarization allows visualization of both collagen fibers (bright/enhanced) and remaining cellular structures. Note the high quality full field illumination and high resolution. Zoom in to see details of cellular, and subcellular structures (nuclei, nucleoli, etc.) Image obtained at 10x mag. with high resolution ProRes camera.

Normal white light image of a hip tissue histology specimen. Notable are the cellular structures surrounding fatty deposits. Zoom in for cellular and subcellular detail!

High resolution (40x) partially polarized light image of fatty tissue from buttocks area. Notable are fine collagen fiber structures and the large lacunae and vessels, surrounded by interesting cell patterning. Large scale images at high resolution are difficult to obtain because of the difficulty of focusing. Consistent per-tile focusing was again achieved using a custom developed algorithm.

More coming soon! (if my bandwidth can handle it :)

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